Document Detail

Perthes' disease in the UK: Geographic and temporal trends in incidence reflecting deprivation inequalities in childhood.
MedLine Citation:
PMID:  22143958     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Perthes' disease is a common childhood precursor to osteoarthritis of the hip, of which little is known. We analysed the UK incidence of disease, with respect to geographic and temporal trends over a 19-year period. METHODS: The General Practice Research database was analysed between 1990 and 2008 to identify incident cases in children aged 0-14 years old. Incidence rates were calculated by year and region, and the association with regional markers of deprivation examined. RESULTS: Over the 19-year period there was a dramatic decline in incidence with annual rates falling from 12·2 to 5·7 cases/100,000 children 0-14 years old (p< 0·001). There was also marked geographic variation with incidence rates in Scotland more than twice those in London (10·39 (95% CI 8·05 - 13·2) vs. 4·6 (95% CI 3·4 - 6·1) per 100,000 0-14 year olds). A more rapid decline in incidence was apparent in the Northern regions compared to Southern regions. The most deprived quintile had the highest disease incidence (rate ratio 1·49 (95% CI 1·10 - 2·04)) and, with the exception of London, regional incidence showed a strong linear relationship to regional deprivation score (p<0·01). CONCLUSION: The incidence of Perthes' disease has a strong North-South divide, with a greater disease incidence within the Northern regions of the UK. There is a marked decline in incidence over the study period, which is more marked in Northern areas. The declining incidence, along with the geographic variation, suggests that a major aetiological determinant in Perthes' disease is environmental, which is closely linked to childhood deprivation.
Daniel C Perry; Colin E Bruce; Daniel Pope; Peter Dangerfield; Mary Jane Platt; Andrew J Hall
Related Documents :
23915378 - Chronic disease mortality in rural and urban residents in hubei province, china, 2008--...
25132518 - Altered manifestations of skin disease at sites affected by neurological deficit.
23146858 - Multifocal venous thrombosis in behcet's disease.
24905548 - Rifampicine: an antibiotic with brain protective function.
20143918 - Lymphatics in idiopathic pulmonary fibrosis: new insights into an old disease.
11977928 - Ischaemic colitis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-5
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Epidemiology PhD Student and Orthopaedic Specialist Registrar, School of Population, Community and Behavioural Science. The University of Liverpool, Whelan Street Building, Liverpool L69 3BX.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Malondialdehyde, Bcl-2, Superoxide Dismutase and Glutathione Peroxidase may Mediate the Association ...
Next Document:  QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study.