Document Detail


Perthes' disease in the UK: Geographic and temporal trends in incidence reflecting deprivation inequalities in childhood.
MedLine Citation:
PMID:  22143958     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Perthes' disease is a common childhood precursor to osteoarthritis of the hip, of which little is known. We analysed the UK incidence of disease, with respect to geographic and temporal trends over a 19-year period. METHODS: The General Practice Research database was analysed between 1990 and 2008 to identify incident cases in children aged 0-14 years old. Incidence rates were calculated by year and region, and the association with regional markers of deprivation examined. RESULTS: Over the 19-year period there was a dramatic decline in incidence with annual rates falling from 12·2 to 5·7 cases/100,000 children 0-14 years old (p< 0·001). There was also marked geographic variation with incidence rates in Scotland more than twice those in London (10·39 (95% CI 8·05 - 13·2) vs. 4·6 (95% CI 3·4 - 6·1) per 100,000 0-14 year olds). A more rapid decline in incidence was apparent in the Northern regions compared to Southern regions. The most deprived quintile had the highest disease incidence (rate ratio 1·49 (95% CI 1·10 - 2·04)) and, with the exception of London, regional incidence showed a strong linear relationship to regional deprivation score (p<0·01). CONCLUSION: The incidence of Perthes' disease has a strong North-South divide, with a greater disease incidence within the Northern regions of the UK. There is a marked decline in incidence over the study period, which is more marked in Northern areas. The declining incidence, along with the geographic variation, suggests that a major aetiological determinant in Perthes' disease is environmental, which is closely linked to childhood deprivation.
Authors:
Daniel C Perry; Colin E Bruce; Daniel Pope; Peter Dangerfield; Mary Jane Platt; Andrew J Hall
Related Documents :
23915378 - Chronic disease mortality in rural and urban residents in hubei province, china, 2008--...
25132518 - Altered manifestations of skin disease at sites affected by neurological deficit.
23146858 - Multifocal venous thrombosis in behcet's disease.
24905548 - Rifampicine: an antibiotic with brain protective function.
20143918 - Lymphatics in idiopathic pulmonary fibrosis: new insights into an old disease.
11977928 - Ischaemic colitis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-5
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Affiliation:
Epidemiology PhD Student and Orthopaedic Specialist Registrar, School of Population, Community and Behavioural Science. The University of Liverpool, Whelan Street Building, Liverpool L69 3BX. danperry@doctors.org.uk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Malondialdehyde, Bcl-2, Superoxide Dismutase and Glutathione Peroxidase may Mediate the Association ...
Next Document:  QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study.