Document Detail

Perspiration increased human pesticide absorption following surface contact during an indoor scripted activity program.
MedLine Citation:
PMID:  15014543     Owner:  NLM     Status:  MEDLINE    
Homeowners and professional applicators frequently use chemicals to control insect pests in urban environments. The identification and evaluation of determinants of human exposure are critical to conduct reliable and responsible human exposure assessments following indoor residential chemical applications. The effect of sweat on absorbed dose in humans was evaluated with human volunteers who participated in a structured activity program (SAP). Participants (n=20) performed a warm-up exercise to induce light sweating prior to an SAP on chlorpyrifos(cp)-treated nylon carpet. Absorbed daily dosages (ADDs) were calculated using urinary biomonitoring of trichloropyridinol. In two separate exposures, participation in the warm-up exercise prior to the exposure SAP resulted in an increased ADD of CP equivalents by approximately 50%. Measured ADDs averaged 2.8 (SAP 1) and 2.0 (SAP 2) microg CP equivalents/kg/day in volunteers who participated in the warm-up exercise. In participants who rested prior to the exposures, ADDs were significantly lower at 1.9 (SAP 1) and 1.3 (SAP 2) microg CP equivalents/kg/day. Perspiration may also be a determinant of exposure in active children and field workers. Measured ADDs were less than estimates of ADD made from environmental measurements including CP deposition, the California roller, and clothing dosimeters worn by participants.
Ryan L Williams; Linda S Aston; Robert I Krieger
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of exposure analysis and environmental epidemiology     Volume:  14     ISSN:  1053-4245     ISO Abbreviation:  J Expo Anal Environ Epidemiol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111438     Medline TA:  J Expo Anal Environ Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
Personal Chemical Exposure Program, Department of Entomology and Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA.
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MeSH Terms
Air Pollution, Indoor* / analysis
Analysis of Variance
Biological Markers
Chlorpyrifos / analysis,  chemistry*,  urine
Pesticides / analysis,  chemistry*,  urine
Pyridones / urine
Skin Absorption / physiology*
Sweat / chemistry*
Reg. No./Substance:
0/Biological Markers; 0/Pesticides; 0/Pyridones; 2921-88-2/Chlorpyrifos; 6515-38-4/3,5,6-trichloro-2-pyridinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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