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Perspectives for the treatment of anemia in heart failure: is there a role for vasopressin antagonists?
MedLine Citation:
PMID:  22277171     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Anemia is an independent predictor of mortality in congestive heart failure patients. Recent studies have recognized that dilutional anemia is highly prevalent in this population. However, the implications for treatment have not been comprehensively elucidated. In this regard, arginine-vasopressin antagonists, by increasing aquaresis, may be an attractive treatment option. Nevertheless, only indirect evidence supports the hypothesis that arginine-vasopressin antagonists may be useful in the treatment of congestive heart failure anemia. Therefore, future clinical research should explore the role of arginine-vasopressin pathway activation in determining dilutional anemia and, ultimately, assess it as a therapeutic target. Congest Heart Fail. 2012;18:1-3. ©2011 Wiley Periodicals, Inc.
Authors:
João Silva Marques
Publication Detail:
Type:  Journal Article     Date:  2011-07-22
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  18     ISSN:  1751-7133     ISO Abbreviation:  Congest Heart Fail     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
From the Department of Cardiology I, CHLN, EPE - University Hospital Santa Maria, Portugal.
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