Document Detail


Perspectives for metabolomics in testosterone replacement therapy.
MedLine Citation:
PMID:  22547567     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Testosterone is the major circulating androgen in men but exhibits an age-related decline in the ageing male. Late-onset hypogonadism or androgen deficiency syndrome (ADS) is a "syndromic" disorder including both a persistent low testosterone serum concentration and major clinical symptoms, including erectile dysfunction, low libido, decreased muscle mass and strength, increased body fat, decreased vitality, or depressed mood. Given its unspecific symptoms, treatment goals, and monitoring parameters, the review will outline the various uncertainties concerning the diagnosis, therapy, and monitoring of ADS to date.The current state of research, showing that metabolomics is starting to have an impact not only on disease diagnosis and prognosis but also on drug treatment efficacy and safety monitoring, will be presented, and the application of metabolomics to improve the clinical management of ADS will be discussed. Finally, the scientific opportunities presented by metabolomics and other -omics as novel and promising tools for biomarker discovery and individualised testosterone replacement therapy in men will be explored.
Authors:
Robin Haring
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-30
Journal Detail:
Title:  The Journal of endocrinology     Volume:  -     ISSN:  1479-6805     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
R Haring, Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, 17475, Germany.
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