Document Detail

Perspectives in cell cycle regulation: lessons from an anoxic vertebrate.
MedLine Citation:
PMID:  20514219     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The ability of an animal, normally dependent on aerobic respiration, to suspend breathing and enter an anoxic state for long term survival is clearly a fascinating feat, and has been the focus of numerous biochemical studies. When anoxia tolerant turtles are faced with periods of oxygen deprivation, numerous physiological and biochemical alterations take place in order to facilitate vital reductions in ATP consumption. Such strategies include reversible post-translational modifications as well as the implementation of translation and transcription controls facilitating metabolic depression. Although it is clear that anoxic survival relies on the suppression of ATP consuming processes, the state of the cell cycle in anoxia tolerant vertebrates remain elusive. Several anoxia tolerant invertebrate and embryonic vertebrate models display cell cycle arrest when presented with anoxic stress. Despite this, the cell cycle has not yet been characterized for anoxia tolerant turtles. Understanding how vertebrates respond to anoxia can have important clinical implications. Uncontrollable cellular proliferation and hypoxic tumor progression are inescapably linked in vertebrate tissues. Consequentially, the molecular mechanisms controlling these processes have profound clinical consequences. This review article will discuss the theory of cell cycle arrest in anoxic vertebrates and more specifically, the control of the retinoblastoma pathway, the molecular markers of cell cycle arrest, the activation of checkpoint kinases, and the possibility of translational controls implemented by microRNAs.
Kyle K Biggar; Kenneth B Storey
Related Documents :
7193969 - The median eminence in normal, ovariectomized, and ovariectomized-estradiol-treated ham...
14967829 - Angiotensin ii and cell cycle regulation.
11448769 - Fission yeast clp1p phosphatase regulates g2/m transition and coordination of cytokines...
12372149 - A genomic approach to studying cell-size homeostasis in yeast.
7555729 - Expression of the cell cycle control gene, cdc25, is constitutive in the segmental foun...
11164189 - Prevention of entrance into g2 cell cycle phase by mimosine decreases locomotion of cel...
15960809 - Biochip sensors for the rapid and sensitive detection of viral disease.
9183669 - Changes in the ultrastructure of human cells related to certain biological responses un...
24984679 - Influence of root conditioning prior to emd application on periodontal ligament cells o...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current genomics     Volume:  10     ISSN:  1875-5488     ISO Abbreviation:  Curr. Genomics     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100960527     Medline TA:  Curr Genomics     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  573-84     Citation Subset:  -    
Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Getting a grip on complexes.
Next Document:  Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson's Disease?