Document Detail

Perspectives on immunoglobulins in colostrum and milk.
MedLine Citation:
PMID:  22254105     Owner:  NLM     Status:  MEDLINE    
Immunoglobulins form an important component of the immunological activity found in milk and colostrum. They are central to the immunological link that occurs when the mother transfers passive immunity to the offspring. The mechanism of transfer varies among mammalian species. Cattle provide a readily available immune rich colostrum and milk in large quantities, making those secretions important potential sources of immune products that may benefit humans. Immune milk is a term used to describe a range of products of the bovine mammary gland that have been tested against several human diseases. The use of colostrum or milk as a source of immunoglobulins, whether intended for the neonate of the species producing the secretion or for a different species, can be viewed in the context of the types of immunoglobulins in the secretion, the mechanisms by which the immunoglobulins are secreted, and the mechanisms by which the neonate or adult consuming the milk then gains immunological benefit. The stability of immunoglobulins as they undergo processing in the milk, or undergo digestion in the intestine, is an additional consideration for evaluating the value of milk immunoglobulins. This review summarizes the fundamental knowledge of immunoglobulins found in colostrum, milk, and immune milk.
Walter L Hurley; Peter K Theil
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-04-14
Journal Detail:
Title:  Nutrients     Volume:  3     ISSN:  2072-6643     ISO Abbreviation:  Nutrients     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-02-08     Completed Date:  2012-04-04     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101521595     Medline TA:  Nutrients     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  442-74     Citation Subset:  IM    
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
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MeSH Terms
Colostrum / immunology*
Diarrhea / immunology
Drug Stability
Immunity, Maternally-Acquired / immunology
Immunization, Passive
Immunoglobulins* / analysis,  immunology
Infant, Newborn
Intestines / immunology
Milk / immunology*
Milk, Human / immunology
Reg. No./Substance:

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