| Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction. | |
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MedLine Citation:
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PMID: 20196727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A key step in assisted reproduction is the assessment of embryo viability in order to identify the embryo(s) most likely to result in pregnancy. Currently used embryo assessment systems are largely based on morphology and cleavage rate. While these systems have been pivotal in improving implantation and pregnancy rates and reducing multiple gestations, their precision is still insufficient. The limitations of strategies based on morphology have led to the investigation of adjunctive technologies for non-invasive assessment of embryo viability in assisted reproduction. These include the measurement of glucose, pyruvate, or amino acid levels in the embryo culture media, assessment of oxygen consumption by the embryo, genomic and proteomic profiling, and most recently, analytical examination of the embryonic metabolome. As the number of ART cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer become an increasingly more important goal for reproductive medicine. |
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Authors:
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F Aydiner; C E Yetkin; E Seli |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current molecular medicine Volume: 10 ISSN: 1875-5666 ISO Abbreviation: Curr. Mol. Med. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-07-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 206-15 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520-8063, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism* Embryo Culture Techniques Embryo Implantation* Female Fertilization in Vitro / methods Genomics / methods Humans Male Metabolomics / methods Oxygen Consumption Pregnancy Pregnancy Rate Proteomics / methods Reproductive Techniques, Assisted* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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