Document Detail

Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction.
MedLine Citation:
PMID:  20196727     Owner:  NLM     Status:  MEDLINE    
A key step in assisted reproduction is the assessment of embryo viability in order to identify the embryo(s) most likely to result in pregnancy. Currently used embryo assessment systems are largely based on morphology and cleavage rate. While these systems have been pivotal in improving implantation and pregnancy rates and reducing multiple gestations, their precision is still insufficient. The limitations of strategies based on morphology have led to the investigation of adjunctive technologies for non-invasive assessment of embryo viability in assisted reproduction. These include the measurement of glucose, pyruvate, or amino acid levels in the embryo culture media, assessment of oxygen consumption by the embryo, genomic and proteomic profiling, and most recently, analytical examination of the embryonic metabolome. As the number of ART cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer become an increasingly more important goal for reproductive medicine.
F Aydiner; C E Yetkin; E Seli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current molecular medicine     Volume:  10     ISSN:  1875-5666     ISO Abbreviation:  Curr. Mol. Med.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093076     Medline TA:  Curr Mol Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  206-15     Citation Subset:  IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520-8063, USA.
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MeSH Terms
Biological Markers / metabolism*
Embryo Culture Techniques
Embryo Implantation*
Fertilization in Vitro / methods
Genomics / methods
Metabolomics / methods
Oxygen Consumption
Pregnancy Rate
Proteomics / methods
Reproductive Techniques, Assisted*
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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