Document Detail

Perspective for the use of genetic transformants in order to enhance the synthesis of the desired metabolites: Engineering chloroplasts of microalgae for the production of bioactive compounds.
MedLine Citation:
PMID:  21520709     Owner:  NLM     Status:  In-Process    
Eukaryotic microalgae have recently gained particular interest as bioreactors because they provide attractive alternatives to bacterial, yeast, plant and other cell-based systems currently in use. Over the last years there has been considerable progress in genetic engineering technologies for algae. Biotechnology companies start to apply these techniques to alter metabolic pathways and express valuable compounds in different cell compartments. In particular, the eukaryotic unicellular alga Chlamydomonas reinhardtii appears to be a most promising cell factory since high amounts of foreign proteins have been expressed in its chloroplast compartment. For this alga the complete nuclear, plastidal and mitochondrial genome sequences have been determined and databases are available for any searching or cloning requirements. Apart from being easily transformable, stable transgenic strains and production volumes in full containment can be obtained within a relatively short time. Furthermore, C. reinhardtii is a green alga which belongs to the category of organisms generally recognized as safe (GRAS status). Thus, enhancing food with edible algae like Chlamydomonas engineered to (over)produce functional ingredients has the potential to become an important factor in food and feed technologies.
Udo Johanningmeier; Dirk Fischer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  698     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2011-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-51     Citation Subset:  IM    
Institut für Pflanzenphysiologie, Martin-Luther Universität Halle-Wittenberg, Weinbergweg 10, D-06120 Halle (Saale), Germany.
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