Document Detail

Perspective: physiological role(s) of the vascular myogenic response.
MedLine Citation:
PMID:  21895845     Owner:  NLM     Status:  MEDLINE    
The vascular myogenic response is an inherent property of VSM in the walls of small arteries and arterioles, allowing these principal resistance segments of the microcirculation to respond to changes in transmural pressure. Elevated intraluminal pressure leads to myogenic constriction, whereas reduced pressure leads to myogenic dilation. This review focuses on the physiological significance of the myogenic response in microvascular networks. First, historical concepts related to the detection of stretch by the vessel wall are reviewed, including the wall tension hypothesis, and the implications of the proposal that the arteriolar network responds to Pp changes as a system of series-coupled myogenic effectors. Next, the role of the myogenic response in the local regulation of blood flow and/or Pc is examined. Finally, the interaction of myogenic constriction and dilation with other local control mechanisms, including metabolic, neural and shear-dependent mechanisms, is discussed. Throughout the review, an attempt is made to integrate historical and current literature with an emphasis on the physiological role, rather than the underlying signaling mechanisms, of this important component of vascular control.
Michael J Davis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  19     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-06-11     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-114     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
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MeSH Terms
Blood Pressure / physiology
Microcirculation / physiology*
Muscle Contraction / physiology*
Muscle, Smooth, Vascular / physiology*
Vasoconstriction / physiology*
Vasodilation / physiology*
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