| "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling. | |
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MedLine Citation:
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PMID: 19931194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BCM faculty members spearheaded the development of a first-generation Personal Genome Profile (Baylor PGP) assay to assist physicians in diagnosing and managing patients in this new era of medicine. The principles that guided the design and implementation of the Baylor PGP were high quality, robustness, low expense, flexibility, practical clinical utility, and the ability to facilitate broad areas of clinical research. The most distinctive feature of the approach taken is an emphasis on extensive screening for rare disease-causing mutations rather than common risk-increasing polymorphisms. Because these variants have large direct effects, the ability to screen for them inexpensively could have a major immediate clinical impact in disease diagnosis, carrier detection, presymptomatic detection of late onset disease, and even prenatal diagnosis. In addition to creating a counseling tool for individual "consumers," this system will fit into the established medical record and be used by physicians involved in direct patient care. This article describes an overall framework for clinical diagnostic array genotyping and the available technologies, as well as highlights the opportunities and challenges for implementation. |
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Authors:
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David J Tweardy; John W Belmont |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-10-06 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 154 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2009-12-15 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 288-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine (Section of Infectious Diseases), Baylor College of Medicine, Houston, Tex. 77030, USA. dtweardy@bcm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Academic Medical Centers Gene Expression Profiling* Genome, Human* Humans Individualized Medicine* / economics, standards |
| Grant Support | |
ID/Acronym/Agency:
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T32 AI055413-06/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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