| Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine. | |
| | |
MedLine Citation:
|
PMID: 23197273 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Since both tumor cells and host immune cell repertoires are diverse and heterogeneous, immune responses against tumor-associated antigens should differ substantially among individual cancer patients. Selection of suitable peptide vaccines for individual patients based on the preexisting host immunity before vaccination could induce potent anti-tumor responses that provide clinical benefit to cancer patients. We have developed a novel immunotherapeutic approach of personalized peptide vaccination (PPV) in which a maximum of four human leukocyte antigen (HLA) class IA-matched peptides are selected for vaccination among pooled peptides on the basis of both HLA class IA type and the preexisting host immunity before vaccination. In this review, we discuss our recent results of preclinical and clinical studies of PPV for various types of advanced cancer. |
| | |
Authors:
|
Masanori Noguchi; Tetsuro Sasada; Kyogo Itoh |
Related Documents
:
|
10435323 - Identification of some important metabolites of boldenone in urine and feces of cattle ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-30 |
Journal Detail:
|
Title: Cancer immunology, immunotherapy : CII Volume: - ISSN: 1432-0851 ISO Abbreviation: Cancer Immunol. Immunother. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8605732 Medline TA: Cancer Immunol Immunother Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Urology, Kurume University School of Medicine, Kurume, Japan, noguchi@med.kurume-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Efficacy and safety of thromboprophylaxis with low-molecular-weight heparin or rivaroxaban in hip an...
Next Document: Speckle tracking echocardiography derived 2-dimensional myocardial strain predicts left ventricular ...