Document Detail


Personalized oncology in interventional radiology.
MedLine Citation:
PMID:  23885909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As personalized medicine becomes more applicable to oncologic practice, image-guided biopsies will be integral for enabling predictive and pharmacodynamic molecular pathology. Interventional radiology has a key role in defining patient-specific management. Advances in diagnostic techniques, genomics, and proteomics enable a window into subcellular mechanisms driving hyperproliferation, metastatic capabilities, and tumor angiogenesis. A new era of personalized medicine has evolved whereby clinical decisions are adjusted according to a patient's molecular profile. Several mutations and key markers already have been introduced into standard oncologic practice. A broader understanding of personalized oncology will help interventionalists play a greater role in therapy selection and discovery.
Authors:
Nadine Abi-Jaoudeh; Austin G Duffy; Tim F Greten; Elise C Kohn; Timothy W I Clark; Bradford J Wood
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Journal of vascular and interventional radiology : JVIR     Volume:  24     ISSN:  1535-7732     ISO Abbreviation:  J Vasc Interv Radiol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-26     Completed Date:  2014-03-06     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  9203369     Medline TA:  J Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-92; quiz 1093     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 SIR. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / therapeutic use*
Genetic Predisposition to Disease
Genetic Testing
Genomics
Humans
Image-Guided Biopsy
Individualized Medicine*
Medical Oncology / methods*
Molecular Targeted Therapy
Neoplasms / drug therapy*,  genetics,  metabolism,  pathology
Patient Selection
Phenotype
Predictive Value of Tests
Radiography, Interventional*
Signal Transduction / drug effects,  genetics
Tumor Markers, Biological / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
Z99 CL999999/CL/CLC NIH HHS; ZIA CL040011-05/CL/CLC NIH HHS; ZIA CL040015-04/CL/CLC NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Tumor Markers, Biological
Comments/Corrections

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