Document Detail

Personalized medicine and ethics.
MedLine Citation:
PMID:  25219077     Owner:  NLM     Status:  In-Process    
An entire series could be dedicated to the topic of ethics in personalized medicine. Due to the advancements in NGS and genetic testing, personalized medicine is no longer something that will occur in the future, the reality is upon us now. Sequencing an individual's genome can have a substantial impact on the patient's treatment and overall quality of life. However, this can open "Pandora's box" especially if an individual does not want to know the information obtained. In addition, will insurance companies require genetic testing in order to pay for a targeted treatment? If the patient refuses to have the genetic testing, will they have to pay for their treatment out of pocket? In the human interest story presented, the researcher and his team discovered over activity of the FTL3 protein through RNA sequencing which resulted in rapid proliferation of his leukemic cells. He identified a drug marketed for advanced kidney cancer which was a FTL3 inhibitor. However, his insurance company refused to pay for the drug because it was not a known treatment for his condition of ALL. He incurred numerous out of pocket expenses in order to go into remission. Was it unethical for the insurance company to not pay for a treatment that ultimately worked but was not marketed or FDA cleared for his type of leukemia? There are so many questions and concerns when personalized medicine is implemented. Only time will tell the effects next generation sequencing and its role in personalized medicine will have in the future.
Deborah Josko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical laboratory science : journal of the American Society for Medical Technology     Volume:  27     ISSN:  0894-959X     ISO Abbreviation:  Clin Lab Sci     Publication Date:  2014  
Date Detail:
Created Date:  2014-09-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806547     Medline TA:  Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  T    
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