| Personalized medicine for AML? | |
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MedLine Citation:
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PMID: 20947687 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Almost a decade ago, Gillil and proposed a model of leukemogenesis for acute myeloid leukemia (AML). In this model, AML results from activating mutations in genes that confer increased proliferation and survival capabilities (class I mutations) acting in concert with chromosomal abnormalities or gene mutations that block differentiation and subsequent apoptosis (class II mutations). In this issue of Blood, Bach as and colleagues present data that clearly demonstrate mutational shifts in class I/II genes that occur between diagnosis and relapse in children with AML. The authors suggest that these findings may allow for personalized treatment. |
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Authors:
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Franklin O Smith |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2010-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 2622-3 Citation Subset: - |
Affiliation:
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Cincinnati Children's Hospital Medical Center, OH, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Comments/Corrections | |
Comment On:
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Blood. 2010 Oct 14;116(15):2752-8
[PMID:
20592250
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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