| Personality and medication non-adherence among older adults enrolled in a six-year trial. | |
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MedLine Citation:
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PMID: 20723339 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives Personality factors parsimoniously capture the variation in dispositional characteristics that affect behaviours, but their value in predicting medication non-adherence is unclear. We investigated the relationship between five-factor model personality factors (Conscientiousness, Neuroticism, Agreeableness, Extraversion, and Openness) and medication non-adherence among older participants during a six-year randomized placebo-controlled trial (RCT). Design Observational cohort data from 771 subjects aged >/=72 years enrolled in the Ginkgo Evaluation of Memory study, a RCT of Ginkgo biloba for prevention of dementia. Methods Random effects logistic regression analyses examined effects of NEO Five-Factor Inventory scores on medication non-adherence, determined via pill counts every 6 months (median follow-up 6.1 years) and defined as taking <80% of prescribed pills. Analyses adjusted for covariates linked with non-adherence in prior studies. Results Each 5 year increment in participant age was associated with a 6.7% greater probability of non-adherence (95% confidence interval, CI [2.4, 11.0]). Neuroticism was the only personality factor associated with non-adherence: a 1 SD increase was associated with a 3.8% increase in the probability of non-adherence (95% CI [0.4, 7.2]). Lower cognitive function was also associated with non-adherence: a 1 SD decrease in mental status exam score was associated with a 3.0% increase in the probability of non-adherence (95% CI [0.2, 5.9]). Conclusions Neuroticism was associated with medication non-adherence over 6 years of follow-up in a large sample of older RCT participants. Personality measurement in clinical and research settings might help to identify and guide interventions for older adults at risk for medication non-adherence. |
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Authors:
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Anthony Jerant; Benjamin Chapman; Paul Duberstein; John Robbins; Peter Franks |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-8-18 |
Journal Detail:
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Title: British journal of health psychology Volume: - ISSN: 1359-107X ISO Abbreviation: - Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-8-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605409 Medline TA: Br J Health Psychol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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