Document Detail

Personality, manual preference and neuroendocrine reactivity in hirsute subjects.
MedLine Citation:
PMID:  15327925     Owner:  NLM     Status:  MEDLINE    
Behavioral and neuroendocrine differences may be postulated in hirsute subjects since central effects of gonadal steroids are well established. We conducted a controlled clinical study with 25 consecutive young hirsute participants compared with 20 consecutive controls. Neuropsychological evaluation included the Minnesota Multiphasic Personality Inventory (MMPI) and the Edinburgh Inventory of Manual Preference (EIMP). Neuroendocrine reactivity was assessed by the adrenocorticotropic hormone (ACTH) and cortisol responses to corticotropin releasing hormone (CRH). Hirsute participants presented a flattened personality profile with lower neurotic triad scores--146 +/- 20 versus 166 +/- 28. Left-hand preference was more common in hirsute participants--4/21 versus 0/20. Decreased ACTH [area under the curve (AUC)--36 +/-2 8 vs. 72 +/- 63 pg/ml h] and cortisol (AUC--18 +/- 4 vs. 25 +/- 10 microg/dl h) responses to CRH were found in the hirsute group. In the hirsute group, higher manual preference scores were associated with lower ACTH responses to CRH, while the opposite association was found in the control group. In the hirsute group, the hyporeactive hypothalamic-pituitary-adrenal (HPA) axis was associated with lower behavior-deviant scores, while in the control group, the hyporeactive HPA axis was associated with more psychopathology. We conclude that personality and HPA axis reactivity are different in hirsute female participants when compared with controls, with a trend for differences regarding handedness. Personality and handedness are differently associated with HPA reactivity. Distinctive features in hirsute participants are probably established very early during ontogenic development.
J Martin Martins; S Do Vale; A Trinca; C Saldanha; J Martins E Silva
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  82     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  741-9     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Elsevier Inc.
Endocrine Unit, Curry Cabral Hospital, Lisbon, Portugal.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Corticotropin-Releasing Hormone / blood
Functional Laterality / physiology*
Hirsutism / blood,  physiopathology,  psychology*
Hormones / blood
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / physiopathology
Neurosecretory Systems / physiopathology*
Personality / physiology*
Personality Tests
Reg. No./Substance:
0/Hormones; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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