| Personality differences in monozygotic twins discordant for cannabis use. | |
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MedLine Citation:
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PMID: 18031429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To explore the association between cannabis and personality scores when genetic background and shared environment are controlled for. DESIGN: The co-twin control design. This design provides a powerful method for controlling for the effects of potentially confounding familial factors that may act to predispose subjects both to cannabis use and a particular personality profile. PARTICIPANTS: 118 monozygotic twin pairs discordant for cannabis use. MEASUREMENTS: Data on personality and cannabis use were obtained through a questionnaire survey. The Dutch Sensation Seeking List was used to assess various aspects of sensation seeking. The Amsterdamse Biografische Vragenlijst assessed extraversion, neuroticism, somatic complaints and test attitude. FINDINGS: The affected twins scored higher on all scales than their unaffected co-twins, especially on experience seeking (P = 0.004), total sensation seeking score (P = 0.004) and neuroticism (P = 0.039). Differences were also observed when items on drug use were removed from the experience seeking scale (P = 0.037) and total sensation seeking score (P = 0.009) although these differences were no longer significant after Bonferoni correction (P < 0.005). CONCLUSIONS: Cannabis use is associated with a higher score on personality scales. This result was obtained in a sample of monozygotic twins discordant for cannabis use. Thus, at least part of the association between cannabis use and experience seeking cannot be attributed to underlying genetic or shared environmental factors that influence both personality and cannabis use and must be explained by unique environmental influences. |
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Authors:
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Jacqueline M Vink; Laura Nawijn; Dorret I Boomsma; Gonneke Willemsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Addiction (Abingdon, England) Volume: 102 ISSN: 0965-2140 ISO Abbreviation: Addiction Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-22 Completed Date: 2008-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304118 Medline TA: Addiction Country: England |
Other Details:
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Languages: eng Pagination: 1942-6 Citation Subset: IM |
Affiliation:
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Department of Biological Psychology, VU University Amsterdam, The Netherlands. jm.vink@psy.vu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Child Humans Marijuana Abuse / epidemiology, psychology* Netherlands / epidemiology Personality / physiology* Statistics as Topic Twins, Monozygotic / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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