Document Detail

Persisting concentrating and second gas effects on oxygenation during N2O anaesthesia.
MedLine Citation:
PMID:  16548949     Owner:  NLM     Status:  MEDLINE    
Theoretical modelling predicts that the concentrating effect of nitrous oxide (N2O) uptake on alveolar oxygenation is a persisting phenomenon at typical levels of ventilation - perfusion (V/Q) inhomogeneity under anaesthesia. We sought clinical confirmation of this in 20 anaesthetised patients. Arterial oxygen pressure (P(aO2)) was measured after a minimum of 30 min of relaxant general anaesthesia with an inspired oxygen (F(I O2)) of 30%. Patients were randomly allocated to two groups. The intervention group had N2O introduced following baseline blood gas measurements, and the control group continued breathing an identical F(I O2) in nitrogen (N2). The primary outcome variable was change in P(aO2). Mean (SD) in P(aO2) was increased by 1.80 (1.80) kPa after receiving a mean of 47.5 min of N2O compared with baseline conditions breathing O2/N2 (p = 0.01). This change was significantly greater (p = 0.03) than that in the control group: + 0.09 (1.37) kPa, p = 0.83 and confirms the presence of significant persisting concentrating and second gas effects.
P J Peyton; C Stuart-Andrews; K Deo; F Strahan; G J B Robinson; B R Thompson; R Pierce
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  61     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-9     Citation Subset:  AIM; IM    
Joint Director of Research, Department of Anaesthesia, Austin Hospital, Heidelberg, 3084, Melbourne, Australia.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Anesthesia, Inhalation / methods
Anesthetics, Inhalation / pharmacology*
Internal Mammary-Coronary Artery Anastomosis
Intraoperative Period
Middle Aged
Nitrous Oxide / pharmacology*
Oxygen / blood
Oxygen Consumption / drug effects*
Partial Pressure
Pulmonary Gas Exchange / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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