Document Detail


Persistent reduced solubilization of immune complexes in lepromatous leprosy patients with reactions.
MedLine Citation:
PMID:  2030316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is held that immune complexes (IC) play a vital role in the pathogenesis of some of the reactions in leprosy. The complement system is known to solubilize and render IC innocuous. We have previously shown that patients undergoing lepra reactions had lowered complement-mediated IC solubilization (CMS). We, therefore, undertook a prospective study of untreated multibacillary leprosy patients and monitored their CMS levels sequentially while on therapy. In addition, the concentrations of the complement component C3d, immunoglobulins G, A and M, and circulating immune complexes (CIC) were also estimated. A total of 26 patients were included in the study and were investigated at 3-month intervals for 3 years. Thirteen of the 14 patients who did not develop reactions at all had normal CMS values, although all of them showed elevated CIC. From the inception of treatment, 10 of the 12 patients who developed lepra reactions had low CMS values which remained below normal levels even after evidence of complement activation disappeared and long after the subsidence of reaction. It is suggested that this defective CMS acts as a predisposing cause of lepra reactions.
Authors:
V D Ramanathan; P Tyagi; U Ramanathan; K Katoch; U Sengupta; G Ramu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  59     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-14     Completed Date:  1991-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Affiliation:
Central JALMA Institute for Leprosy, Taj Ganj, Agra, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigen-Antibody Complex / blood,  chemistry*
Complement C3d / analysis
Humans
Immunoglobulins / analysis
Leprosy, Borderline / immunology*
Leprosy, Lepromatous / immunology*
Prospective Studies
Solubility
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulins; 80295-45-0/Complement C3d

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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