Document Detail


Persistent pulmonary hypertension of the newborn: therapeutical approach.
MedLine Citation:
PMID:  19075808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Persistent pulmonary hypertension of the newborn (PPHN), is defined as a failure of the pulmonary vasculature to relax at birth and consequently of the normal adaptation to extra uterine life of the fetal heart/lung system, resulting in hypoxemia. This condition, occurs in about 1-2 newborns per 1000 live births and despite significant improvements in treatment it is associated with substantial infant mortality and morbidity. Over the years wider application of inhaled nitric oxide (iNO) therapy and improved ventilation strategies including surfactant, high-frequency oscillatory ventilation has led to a decrease in the need for invasive life-sustaining therapies such as extracorporeal membrane oxygenation (ECMO). Mortality rate varies from 10 to 20 % of affected newborns in developed countries, but it is much higher when PPHN is refractory to the above reported therapies or when they are not available. As a consequence, development of new therapeutic strategies for severe PPHN is crucial. In particular, recent studies seem to show that sildenafil, a phosphodiesterase inhibitor type 5 that selectively reduces pulmonary vascular resistance may be a useful therapeutic adjunct to critically ill neonates with PPHN.
Authors:
Giuseppe Latini; Antonio Del Vecchio; Claudio De Felice; Alberto Verrotti; Eduardo Bossone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  8     ISSN:  1389-5575     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1507-13     Citation Subset:  IM    
Affiliation:
Division of Neonatology, Perrino Hospital, s.s. 7 per Mesagne, 72100 Brindisi, Italy. gilatini@tin.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Humans
Infant, Newborn
Milrinone / therapeutic use*
Nitric Oxide / administration & dosage,  therapeutic use*
Persistent Fetal Circulation Syndrome / drug therapy*
Piperazines / therapeutic use*
Purines / therapeutic use
Sulfones / therapeutic use*
Chemical
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 10102-43-9/Nitric Oxide; 139755-83-2/sildenafil; 78415-72-2/Milrinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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