Document Detail


Persistent pulmonary hypertension of the newborn and selective serotonin reuptake inhibitors: lessons from clinical and translational studies.
MedLine Citation:
PMID:  22420034     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Two recent studies linking in utero exposure to selective serotonin reuptake inhibitors (SSRIs) with persistent pulmonary hypertension of the newborn (PPHN), a potentially serious but rare respiratory illness, have made clinicians and patients more reluctant to use SSRIs during pregnancy. However, additional clinical studies have associated maternal depression rather than SSRI exposure as a risk factor for PPHN. This review summarizes the current knowledge regarding PPHN pathophysiology, including the role of serotonin and genetic risk factors; the effects of SSRIs on pulmonary vasculature; the possible link between SSRIs and PPHN; and the diagnosis, clinical management, and prognosis of PPHN.
Authors:
Mallay Occhiogrosso; Setareh Salehi Omran; Margaret Altemus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  169     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry at Weill Cornell Medical College in New York, USA. mbc2003@med.cornell.edu
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Comment In:
Am J Psychiatry. 2012 Feb;169(2):121-4   [PMID:  22318792 ]

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