| Persistent pulmonary hypertension of the newborn and selective serotonin reuptake inhibitors: lessons from clinical and translational studies. | |
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MedLine Citation:
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PMID: 22420034 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Two recent studies linking in utero exposure to selective serotonin reuptake inhibitors (SSRIs) with persistent pulmonary hypertension of the newborn (PPHN), a potentially serious but rare respiratory illness, have made clinicians and patients more reluctant to use SSRIs during pregnancy. However, additional clinical studies have associated maternal depression rather than SSRI exposure as a risk factor for PPHN. This review summarizes the current knowledge regarding PPHN pathophysiology, including the role of serotonin and genetic risk factors; the effects of SSRIs on pulmonary vasculature; the possible link between SSRIs and PPHN; and the diagnosis, clinical management, and prognosis of PPHN. |
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Authors:
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Mallay Occhiogrosso; Setareh Salehi Omran; Margaret Altemus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of psychiatry Volume: 169 ISSN: 1535-7228 ISO Abbreviation: Am J Psychiatry Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 134-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry at Weill Cornell Medical College in New York, USA. mbc2003@med.cornell.edu |
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| Comments/Corrections | |
Comment In:
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Am J Psychiatry. 2012 Feb;169(2):121-4
[PMID:
22318792
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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