Document Detail

Persistent pulmonary hypertension in preterm-infants.
MedLine Citation:
PMID:  3083387     Owner:  NLM     Status:  MEDLINE    
Persistent pulmonary hypertension of the newborn (PPHN) is a cyanotic syndrome that occurs primarily in full-term and postmature infants and causes right-to-left shunts at the atrial or ductal levels or both. Term babies with PPHN show structural changes in pulmonary vascular smooth muscle as a result of chronic prenatal distress. It is our opinion that in preterm babies the PPHN syndrome also exists. In this group of patients the potential pathways to the persistence of high pulmonary vascular resistence are only functional vascular changes precipitated by acute perinatal stress. The cyanosis of PPHN is rapidly regredient in preterm infants and clinical resolution occurs promptly if the diagnosis is correct and the treatment is started as early as possible in centers capable of extensive monitoring and neonatal supportive care to minimize the risks of Tolazoline therapy.
M Amato; B de Roche; G von Muralt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pädiatrie und Pädologie     Volume:  21     ISSN:  0030-9338     ISO Abbreviation:  Padiatr Padol     Publication Date:  1986  
Date Detail:
Created Date:  1986-05-16     Completed Date:  1986-05-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0022370     Medline TA:  Padiatr Padol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / blood
Ductus Arteriosus, Patent / diagnosis
Gestational Age
Hypertension, Pulmonary / congenital*,  diagnosis
Infant, Newborn
Infant, Premature, Diseases / diagnosis*
Oxygen / blood
Persistent Fetal Circulation Syndrome / diagnosis
Pulmonary Circulation
Respiration, Artificial
Vascular Resistance
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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