| Persistent pulmonary hypertension: assessment of perinatal risk factors. | |
| | |
MedLine Citation:
|
PMID: 3658275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Persistent pulmonary hypertension of the neonate, a disease of unknown etiology, is associated with a mortality rate as high as 50%. We conducted a retrospective study (1979-1983) to identify antenatal events that may be associated with this disease. Thirty-seven mothers of neonates with this disorder were compared with 150 randomly selected control patients. Logistic regression analysis revealed that meconium, maternal fever (caused by urinary tract infection, upper respiratory infection, chorioamnionitis, and unknown causes), maternal anemia (caused by abruptio placentae, placenta previa, and unknown causes), and maternal pulmonary disease (caused by asthma and/or pneumonia) were associated with persistent pulmonary hypertension of the neonate. The computed odds ratios for the variables associated with this disease were increased significantly above the controls. In addition, cesarean section, nonvertex presentation, fetal distress, and vaginal bleeding were found to be significant on univariate analyses. The cesarean section rate in the study group was 59%, with the primary indications of fetal distress and/or third-trimester bleeding in 77.3% of instances. These data suggest that antenatal risk factors and the computed odds ratio may help identify pregnancies likely to produce infants at high risk for persistent pulmonary hypertension of the neonate. |
| | |
Authors:
|
E A Reece; F Moya; R Yazigi; T Holford; C Duncan; R A Ehrenkranz |
Related Documents
:
|
16132305 - Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital ... 9390915 - Neonatal pulmonary function testing. 9376005 - Increased acinar arterial wall muscle in preterm infants with prom and pulmonary hypopl... 15342985 - Kl-6: marker for pulmonary involvement in langerhans cell histiocytosis in infants. 23201835 - How feasible is baby-led weaning as an approach to infant feeding? a review of the evid... 3517795 - Real-time ultrasonographic surveillance in the detection of cns involvement in systemic... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Obstetrics and gynecology Volume: 70 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1987 Nov |
Date Detail:
|
Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2009-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 696-700 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Asphyxia Neonatorum
/
complications Cesarean Section / adverse effects Female Gestational Age Humans Infant, Newborn Persistent Fetal Circulation Syndrome / etiology* Pregnancy Pregnancy Complications Respiratory Distress Syndrome, Newborn / complications Retrospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nuchal cords and neonatal outcome.
Next Document: Antepartum ambulatory tocodynamometry: the significance of low-amplitude, high-frequency contraction...