Document Detail

Persistent organochlorine residues in human breast milk from Hanoi and Hochiminh City, Vietnam: contamination, accumulation kinetics and risk assessment for infants.
MedLine Citation:
PMID:  15016464     Owner:  NLM     Status:  MEDLINE    
Despite the ban on persistent organochlorines (OCs) in most of the developed nations, their usage continued until recently in many Asian developing countries including Vietnam, for agricultural purposes and vector-borne disease eradication programs. In this study, we collected human breast milk samples from the two big cities in Vietnam: Hanoi (n=42) and Hochiminh (n=44) and determined the concentrations of persistent OCs such as PCBs, DDT and its metabolites (DDTs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), chlordane compounds (CHLs) and tris-4-chlorophenyl-methane (TCPMe). The contamination pattern of OCs was in the order of DDTs > PCBs > HCHs > CHLs approximately HCB approximately TCPMe. Compilation of available data indicated that DDT residue levels in human breast milk from Vietnam were among the highest values reported for Asian developing countries as well as developed nations. This result suggests recent usage of DDTs in both north and south Vietnam. Interestingly, in both cities, the p,p'-DDT portion was higher in multiparas than those in primiparas. Considering the fact that the interval between the first and the second child of a mother in Vietnam is usually short, this result probably indicates continuous intake of DDTs in the population. Analysis of infant exposure to DDTs via breast milk suggested that the daily intake rates for number of individuals are close to or above the threshold for adverse effects which may raise concern on children health.
Nguyen Hung Minh; Masayuki Someya; Tu Binh Minh; Tatsuya Kunisue; Hisato Iwata; Mafumi Watanabe; Shinsuke Tanabe; Pham Hung Viet; Bui Cach Tuyen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  129     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-03-12     Completed Date:  2004-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-41     Citation Subset:  IM    
Center for Marine Environmental Studies, Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
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MeSH Terms
Age Factors
Chlordan / analysis,  pharmacokinetics
DDT / analysis,  pharmacokinetics
Developing Countries
Developmental Disabilities / chemically induced
Environmental Exposure / adverse effects
Insecticides / analysis*,  pharmacokinetics
Lindane / analysis,  pharmacokinetics
Milk, Human / chemistry*
Pesticide Residues / analysis*,  pharmacokinetics
Polychlorinated Biphenyls / analysis,  pharmacokinetics
Risk Assessment / methods
Reg. No./Substance:
0/Insecticides; 0/Pesticide Residues; 0/Polychlorinated Biphenyls; 12789-03-6/Chlordan; 50-29-3/DDT; 58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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