| Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 2: Correlations among PCBs, PCDD/PCDFs and the use of predictive markers. | |
| | |
MedLine Citation:
|
PMID: 12222776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In 1999, the FLEHS was set by the Flemish Ministry of Health, Belgium to assess pollutant concentrations and related health effect biomarkers in humans living in Flanders. Concentrations of selected organochlorine pesticides, polychlorinated biphenyls (PCB) and polychlorinated dibenzo-p-dioxins (PCDD) and furans (PCDF) were measured by gas chromatography-mass spectrometry and Chemical-Activated LUciferase gene eXpression (CALUX) bioassay in 47 serum pools of 200 women between 50 and 65 years living in two areas of Flanders. Correlation between TEQ values of different groups of compounds were computed in these pool results and it was found that total toxic equivalencies (TEQs) correlated well with the values of the groups of contributing compounds: mono-ortho PCBs (r = 0.77), non-ortho PCBs (r = 0.65) and PCDD/Fs (r = 0.88). The total TEQ was lower correlated to the CALUX-TEQ (r = 0.57). When calculating associations between those classes of compounds in the two studied regions separately, they were all higher correlated in the urban area compared to the more rural region. High correlation coefficients (r > 0.80) were also calculated between individual compounds and groups of compounds. It was suggested that in this studied background-exposed population, some compounds could be good predictors for a group: e.g. PCB 153 for indicator and total PCBs, PCB 118 for total PCB TEQ, PCB 156 for mono-ortho PCB-TEQs and total TEQ, 2,3,4,7,8-P5CDF for PCDD/F TEQs and total TEQs. This means that in pooled serum samples correlations between persistent organochlorine compounds are as strong as for individual POP measurements observed in earlier studies. |
| | |
Authors:
|
Adrian Covaci; Gudrun Koppen; Rudy Van Cleuvenbergen; Paul Schepens; Gerhard Winneke; Nicolas van Larebeke; Vera Nelen; Robert Vlietinck; Greet Schoeters |
Related Documents
:
|
19665796 - Biomagnification of anthropogenic and naturally-produced organobrominated compounds in ... 16201616 - Persistent organic pollutants in british columbia grizzly bears: consequence of diverge... 16212986 - The dependence of organohalogen compound concentrations on herring age and size in the ... 14559266 - Levels of pcdds, pcdfs and pcbs in belgian and international fast food samples. 22778906 - Control of ochratoxin a production in grapes. 19298416 - Schools and obesity prevention: creating school environments and policies to promote he... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Chemosphere Volume: 48 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-09-11 Completed Date: 2003-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
|
Languages: eng Pagination: 827-32 Citation Subset: IM |
Affiliation:
|
Toxicological Center, University of Antwerp, Antwerpen (Wilrijk), Belgium. covaci@uia.ua.ac.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Benzofurans / blood* Biological Markers / analysis* Environmental Exposure Environmental Pollutants / blood* Female Forecasting Humans Insecticides / blood* Middle Aged Netherlands Polychlorinated Biphenyls / blood* Predictive Value of Tests Reference Values Rural Population Soil Pollutants / blood* Tetrachlorodibenzodioxin / analogs & derivatives*, blood* Urban Population |
| Chemical | |
Reg. No./Substance:
|
0/Benzofurans; 0/Biological Markers; 0/Environmental Pollutants; 0/Insecticides; 0/Polychlorinated Biphenyls; 0/Soil Pollutants; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environ...
Next Document: Comparison of dioxin and furan TEQ determination in contaminated soil using chemical, micro-EROD, an...