Document Detail


Persistent organochlorine compounds in human breast milk from mothers living in Penang and Kedah, Malaysia.
MedLine Citation:
PMID:  16132420     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study determined the concentrations of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides, and tris(4-chlorophenyl) methane (TCPMe) in human breast milk samples collected in 2003 from primipara mothers living in Penang, Malaysia. OCs were detected in all the samples analyzed with DDTs, hexachlorocyclohexane isomers (HCHs), and PCBs as the major contaminants followed by chlordane compounds (CHLs), hexachlorobenzene (HCB), and TCPMe. The residue levels of DDTs, HCHs, and CHLs were comparable to or higher than those in general populations of other countries, whereas PCBs and HCB were relatively low. In addition, dioxins and related compounds were also detected with a range of dioxin equivalent concentrations from 3.4 to 24 pg-TEQs/g lipid wt. Levels of toxic equivalents (TEQs) were slightly higher than those in other developing countries but still much lower than those of industrialized nations. One donor mother contained a high TEQs level, equal to the mean value in human breast milk from Japan, implying that some of the residents in Malaysia may be exposed to specific pollution sources of dioxins and related compounds. No association was observed between OCs concentrations and maternal characteristics, which might be related to a limited number of samples, narrow range of age of the donor mothers, and/or other external factors. The recently identified endocrine disrupter, TCPMe, was also detected in all human breast milk samples of this study. A significant positive correlation was observed between TCPMe and DDTs, suggesting that technical DDT might be a source of TCPMe in Malaysia. The present study provides a useful baseline for future studies on the accumulations of OCs in the general population of Malaysia.
Authors:
Agus Sudaryanto; Tatsuya Kunisue; Shinsuke Tanabe; Mami Niida; Hatijah Hashim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-24
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  49     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-22     Completed Date:  2005-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-37     Citation Subset:  IM    
Affiliation:
Center for Marine Environmental Studies, Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Environmental Monitoring
Environmental Pollutants / analysis*,  metabolism,  standards
Female
Humans
Hydrocarbons, Chlorinated / analysis*,  metabolism,  standards
Infant
Infant, Newborn
Insecticides / analysis,  metabolism,  standards
Malaysia
Maternal Exposure*
Milk, Human / chemistry*
Mothers
Pesticide Residues / analysis,  metabolism,  standards
Risk Assessment
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Hydrocarbons, Chlorinated; 0/Insecticides; 0/Pesticide Residues

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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