| Persistent neuropathy and hyperkeratosis from distant arsenic exposure. | |
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MedLine Citation:
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PMID: 16702122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this case series is to assess long-term sequelae of arsenic exposure in a cohort acutely exposed to arsenic in drinking water from a well dug into a landfill containing arsenical pesticides. Ten of the 13 individuals (or next of kin) in the initial study agreed to participate in the follow-up study. Next of kin provided questionnaire data and released medical information on the three individuals who had died. The remaining seven cohort members were assessed by an interview, questionnaire, detailed physical examination and sensory nerve testing. Available medical records were obtained and reviewed. Sensory testing was performed using an automated electrodiagnostic sensory Nerve Conduction Threshold (sNCT) evaluation. Sensory complaints and electrodiagnostic findings consistent with polyneuropathy were found in a minority (3/7) of subjects 28 years after an acute toxic arsenic exposure. Two of the seven patients examined (1 of 3 with neuropathic findings) also had hyperkeratotic lesions consistent with arsenic toxicity and one of the patients had hyperpigmentation on their lower extremities possibly consistent with arsenic toxicity. |
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Authors:
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Beth A Baker; Andrew R Topliff; Rita B Messing; Deborah Durkin; Jean Small Johnson |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of agromedicine Volume: 10 ISSN: 1059-924X ISO Abbreviation: J Agromedicine Publication Date: 2005 |
Date Detail:
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Created Date: 2006-05-16 Completed Date: 2006-08-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421530 Medline TA: J Agromedicine Country: United States |
Other Details:
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Languages: eng Pagination: 43-54 Citation Subset: IM |
Affiliation:
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Occupational and Environmental Medicine, Regions Medical Center, 640 Jackson St, St. Paul, MN 55101, USA. beth.a.baker@healthpartners.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arsenic / adverse effects* Arsenic Poisoning / mortality, physiopathology* Cohort Studies Fatal Outcome Female Humans Male Middle Aged Neural Conduction / drug effects Peripheral Nervous System Diseases / chemically induced, epidemiology*, pathology Skin Diseases / chemically induced, epidemiology*, pathology Water Supply |
| Chemical | |
Reg. No./Substance:
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7440-38-2/Arsenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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