| Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. | |
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MedLine Citation:
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PMID: 20733156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extrahepatic manifestations of hepatitis C virus (HCV) infection occur in 40%-70% of HCV-infected patients. B-cell non-Hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with HCV infection. The mechanism by which HCV infection of B cells leads to lymphoma remains unclear. Here we established HCV transgenic mice that express the full HCV genome in B cells (RzCD19Cre mice) and observed a 25.0% incidence of diffuse large B-cell non-Hodgkin lymphomas (22.2% in males and 29.6% in females) within 600 days after birth. Expression levels of aspartate aminotransferase and alanine aminotransferase, as well as 32 different cytokines, chemokines and growth factors, were examined. The incidence of B-cell lymphoma was significantly correlated with only the level of soluble interleukin-2 receptor α subunit (sIL-2Rα) in RzCD19Cre mouse serum. All RzCD19Cre mice with substantially elevated serum sIL-2Rα levels (> 1000 pg/mL) developed B-cell lymphomas. Moreover, compared with tissues from control animals, the B-cell lymphoma tissues of RzCD19Cre mice expressed significantly higher levels of IL-2Rα. We show that the expression of HCV in B cells promotes non-Hodgkin-type diffuse B-cell lymphoma, and therefore, the RzCD19Cre mouse is a powerful model to study the mechanisms related to the development of HCV-associated B-cell lymphoma. |
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Authors:
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Yuri Kasama; Satoshi Sekiguchi; Makoto Saito; Kousuke Tanaka; Masaaki Satoh; Kazuhiko Kuwahara; Nobuo Sakaguchi; Motohiro Takeya; Yoichi Hiasa; Michinori Kohara; Kyoko Tsukiyama-Kohara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-23 |
Journal Detail:
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Title: Blood Volume: 116 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: 2011-01-06 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 4926-33 Citation Subset: AIM; IM |
Affiliation:
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Department of Experimental Phylaxiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Transformation, Neoplastic / genetics* Cell Transformation, Viral / genetics Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Genes, Viral Hepacivirus / genetics* Immunohistochemistry Interleukin-2 Receptor alpha Subunit / biosynthesis Lymphoma, Large B-Cell, Diffuse / pathology, virology* Male Mice Mice, Transgenic RNA, Messenger / analysis Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 Receptor alpha Subunit; 0/RNA, Messenger |
| Comments/Corrections | |
Erratum In:
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Blood. 2011 May 26;117(21):5782-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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