Document Detail

Persistent erythema and pruritus, with a confluent histiocytic skin infiltrate, following the use of a hydroxyethylstarch plasma expander.
MedLine Citation:
PMID:  8746356     Owner:  NLM     Status:  MEDLINE    
A 40-year-old woman developed a persistent pruritus with erythema of the head and upper trunk, which started within 2 weeks of a hydroxyethylstarch (HES) infusion and was still present 2 years later. Histological examination demonstrated a striking dermal infiltrate of KP1-positive foamy macrophages which had electron-lucent vacuoles. The timing of the onset, the body site distribution, the exclusion of other possibilities and an appropriate history of high dosage HES infusion, suggested that this was the cause of the eruption. Staining with periodic acid-Schiff (PAS) surprisingly was negative but we could not stain HES in vitro with this histochemical stain, and we postulate that the unique extent of the infiltrate and the negative PAS stain in our patient may indicate an impaired ability to degrade this chemical. This may be an important factor in the poorly understood pathogenesis of persistent pruritus induced by HES.
N H Cox; A W Popple
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  134     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  IM    
Department of Dermatology, Cumberland Infirmary, Carlisle, Cumbria, U.K.
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MeSH Terms
Drug Eruptions / etiology*,  pathology
Erythema / chemically induced*,  pathology
Hetastarch / adverse effects*
Histiocytes / pathology
Plasma Substitutes / adverse effects*
Pruritus / chemically induced*
Reg. No./Substance:
0/Plasma Substitutes; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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