Document Detail

Persistent cognitive and motor deficits following acute hydrogen sulphide poisoning.
MedLine Citation:
PMID:  9800424     Owner:  NLM     Status:  MEDLINE    
This case study describes the long-term after-effects of hydrogen sulphide exposure in a previously health 27-year-old male. Upon hospital admission the patient had a Glasgow Coma Score (CGS) of 3; with emergency treatment including hyperbaric oxygen treatments, he progressed to a GCS of 15 on day 7. Although both CT and MRI scans were unremarkable, PET using F-18 deoxyglucose administered 3 years after the accident showed abnormally decreased metabolism bilaterally in the temporal and inferior parietal lobes as well as the left thalamus. Uptake in the striatum was heterogeneous and abnormal. A cerebral perfusion study using SPECT performed 3.5 years after the accident revealed bilaterally decreased flow in the putamen but no cortical abnormalities. Neuropsychological and neurofunctional testing revealed the following impairments: microsmia, psychomotor slowing, extrapyramidal signs and deficits in memory and executive/planning functioning. These findings are discussed in the context of hydrogen sulphide's known mechanisms of toxicity and the functions of the basal ganglia.
J S Schneider; E H Tobe; P D Mozley; L Barniskis; T I Lidsky
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Occupational medicine (Oxford, England)     Volume:  48     ISSN:  0962-7480     ISO Abbreviation:  Occup Med (Lond)     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-11-12     Completed Date:  1998-11-12     Revised Date:  2006-04-19    
Medline Journal Info:
Nlm Unique ID:  9205857     Medline TA:  Occup Med (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Thomas Jefferson University Medical School, Department of Pathology, Philadelphia, PA 19107, USA.
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MeSH Terms
Cognition Disorders / chemically induced*
Hydrogen Sulfide / poisoning*
Magnetic Resonance Imaging
Neuropsychological Tests
Occupational Exposure / adverse effects*
Psychomotor Disorders / chemically induced*
Sanitary Engineering*
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Sewage; 7783-06-4/Hydrogen Sulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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