Document Detail

Persistent T-wave changes after radiofrequency catheter ablation of an accessory connection (Wolff-parkinson-white syndrome) are caused by "cardiac memory".
MedLine Citation:
PMID:  10539834     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to determine the incidence and origin of T-wave changes after ablation of an accessory atrioventricular connection (AC), which could either be a sign of damage to the coronary circulation or a result of persistent abnormal repolarization secondary to previously abnormal ventricular activation ("cardiac memory"). METHODS AND RESULTS: Ninety of 107 consecutive patients (33 women and 57 men, mean age 36 +/- 5 years) undergoing successful catheter ablation of an AC were studied. Patients with bundle branch block or more than 1 AC were excluded. Sixty-four patients had manifest preexcitation (group 1) and 26 had a concealed AC (group 2). Immediately after loss of preexcitation, 38 (59%) patients with a manifest AC showed T-wave abnormalities. In contrast, none of the patients with a concealed AC had T-wave abnormalities after ablation (P <.05). The T-wave changes (1) did not correlate with the number or duration of energy applications or with markers of tissue injury; (2) correlated with the location of the AC and the degree of preexcitation, respectively; and (3) completely resolved over a period of weeks to months. None of the patients had recurrence of preexcitation or tachycardia during a mean follow-up of 16 +/- 7 months. CONCLUSIONS: T-wave changes after ablation are most likely caused by "cardiac memory" and are not a sign of myocardial or coronary injury.
J C Geller; M D Carlson; A Goette; S Reek; W M Hartung; H U Klein
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  138     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-19     Completed Date:  1999-11-19     Revised Date:  2009-12-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  987-93     Citation Subset:  AIM; IM    
Division of Cardiology, University Hospitals, Otto-von-Guericke Magdeburg, Germany.
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MeSH Terms
Atrioventricular Node / surgery*
Catheter Ablation / adverse effects*
Coronary Circulation
Coronary Vessels / injuries,  innervation*
Diagnosis, Differential
Myocardial Ischemia / diagnosis,  etiology*,  physiopathology
Observer Variation
Reproducibility of Results
Treatment Outcome
Wolff-Parkinson-White Syndrome / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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