Document Detail

Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling. A case report and review of the literature.
MedLine Citation:
PMID:  22440599     Owner:  NLM     Status:  MEDLINE    
Neurotoxicity from iodinated contrast agents is a known but rare complication of angiography and neurovascular intervention. Neurotoxicity results from contrast penetrating the blood-brain barrier with resultant cerebral oedema and altered neuronal excitability. Clinical effects include encephalopathy, seizures, cortical blindness and focal neurological deficits. Contrast induced encephalopathy is extensively reported as a transient and reversible phenomenon. We describe a patient with a persistent motor deficit due to an encephalopathy from iodinated contrast media administered during cerebral aneurysm coiling. This observation and a review of the literature highlights that contrast-induced encephalopathy may not always have a benign outcome and can cause permanent deficits. This potential harmful effect should be recognised by the angiographer and the interventionalist.
S Leong; N F Fanning
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-03-16
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  18     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-05-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  33-41     Citation Subset:  IM    
Department of Radiology, Cork University Hospital, Ireland.
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MeSH Terms
Cerebral Angiography / adverse effects*
Contrast Media / adverse effects*
Embolization, Therapeutic*
Intracranial Aneurysm / radiography*,  therapy*
Iodine Radioisotopes / adverse effects
Middle Aged
Neurotoxicity Syndromes / etiology*
Tomography, X-Ray Computed / adverse effects
Reg. No./Substance:
0/Contrast Media; 0/Iodine Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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