| Persistent Fetal Sinus Bradycardia Associated with Maternal Anti-SSA/Ro and Anti-SSB/La Antibodies. | |
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MedLine Citation:
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PMID: 22089457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. METHODS: We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. RESULTS: Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. CONCLUSION: Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement. |
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Authors:
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Priya Chockalingam; Edgar T Jaeggi; Lukas A Rammeloo; Monique C Haak; Phebe N Adama van Scheltema; Johannes M P J Breur; Margot M Bartelings; Sally-Ann B Clur; Nico A Blom |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
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Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Departments of Pediatric Cardiology at Academic Medical Centre, Amsterdam; VU University Medical Centre, Amsterdam; Leiden University Medical Centre, Leiden; and University Medical Centre, Utrecht; Departments of Obstetrics and Gynecology, VU University Medical Centre, Amsterdam; Leiden University Medical Centre, Leiden; and Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands; and Fetal Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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