Document Detail

Persistent Fetal Sinus Bradycardia Associated with Maternal Anti-SSA/Ro and Anti-SSB/La Antibodies.
MedLine Citation:
PMID:  22089457     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. METHODS: We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. RESULTS: Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. CONCLUSION: Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement.
Priya Chockalingam; Edgar T Jaeggi; Lukas A Rammeloo; Monique C Haak; Phebe N Adama van Scheltema; Johannes M P J Breur; Margot M Bartelings; Sally-Ann B Clur; Nico A Blom
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  -     ISSN:  0315-162X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Departments of Pediatric Cardiology at Academic Medical Centre, Amsterdam; VU University Medical Centre, Amsterdam; Leiden University Medical Centre, Leiden; and University Medical Centre, Utrecht; Departments of Obstetrics and Gynecology, VU University Medical Centre, Amsterdam; Leiden University Medical Centre, Leiden; and Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands; and Fetal Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
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