Document Detail

Persistent Coxsackie B encephalitis: Report of a case and review of the literature.
MedLine Citation:
PMID:  17162666     Owner:  NLM     Status:  MEDLINE    
Although the diagnosis is rarely confirmed, enteroviruses are a common cause of meningitis. Coxsackie B is responsible for more than half of the cases of aseptic meningitis in infants less than 3 months old, but is less common as a cause of neurological disease in older persons. In addition to aseptic meningitis, Coxsackie B has been reported to cause a wide range of other neurological disorders, albeit rarely. The authors report a young adult with persistent Coxsackie B encephalitis that was heralded by focal seizures and evolved to intractable coma with multifocal myoclonus. The diagnosis was established by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) on tissue obtained at brain biopsy. Cerebrospinal fluid (CSF) viral cultures and PCR were negative for enteroviruses. This case highlights unusual features of a persistent infection that could easily have been mistaken for a neurodegenerative or other noninfectious process. It also emphasizes the importance of performing brain biopsy on individuals with neurological disease of obscure nature.
Joseph R Berger; Warren Chumley; Thomas Pittman; Curtis Given; Gerard Nuovo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurovirology     Volume:  12     ISSN:  1355-0284     ISO Abbreviation:  J. Neurovirol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508123     Medline TA:  J Neurovirol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-6     Citation Subset:  IM    
Department of Neurology, Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0284, USA.
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MeSH Terms
Brain / pathology*,  virology*
Diagnosis, Differential
Encephalitis, Viral / diagnosis*
Enterovirus B, Human
Enterovirus Infections / complications,  pathology*,  physiopathology*
Magnetic Resonance Imaging
Neurodegenerative Diseases
Reverse Transcriptase Polymerase Chain Reaction
Seizures / etiology
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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