| Persistent Coxsackie B encephalitis: Report of a case and review of the literature. | |
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MedLine Citation:
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PMID: 17162666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the diagnosis is rarely confirmed, enteroviruses are a common cause of meningitis. Coxsackie B is responsible for more than half of the cases of aseptic meningitis in infants less than 3 months old, but is less common as a cause of neurological disease in older persons. In addition to aseptic meningitis, Coxsackie B has been reported to cause a wide range of other neurological disorders, albeit rarely. The authors report a young adult with persistent Coxsackie B encephalitis that was heralded by focal seizures and evolved to intractable coma with multifocal myoclonus. The diagnosis was established by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) on tissue obtained at brain biopsy. Cerebrospinal fluid (CSF) viral cultures and PCR were negative for enteroviruses. This case highlights unusual features of a persistent infection that could easily have been mistaken for a neurodegenerative or other noninfectious process. It also emphasizes the importance of performing brain biopsy on individuals with neurological disease of obscure nature. |
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Authors:
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Joseph R Berger; Warren Chumley; Thomas Pittman; Curtis Given; Gerard Nuovo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurovirology Volume: 12 ISSN: 1355-0284 ISO Abbreviation: J. Neurovirol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508123 Medline TA: J Neurovirol Country: United States |
Other Details:
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Languages: eng Pagination: 511-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0284, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Brain / pathology*, virology* Diagnosis, Differential Encephalitis, Viral / diagnosis* Enterovirus B, Human Enterovirus Infections / complications, pathology*, physiopathology* Female Humans Immunohistochemistry Magnetic Resonance Imaging Neurodegenerative Diseases Reverse Transcriptase Polymerase Chain Reaction Seizures / etiology Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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