Document Detail

Persistent 24-h variations of urinary 6-hydroxy melatonin sulphate and cortisol in Antarctica.
MedLine Citation:
PMID:  3956695     Owner:  NLM     Status:  MEDLINE    
Bright light (2000-3000 lux) of sufficient intensity to suppress human melatonin secretion, acts as a strong zeitgeber in the entrainment of circadian rhythms in man. In polar conditions, light of this intensity is not experienced for several weeks during the winter. The entrainment of human circadian rhythms, in particular that of melatonin, is clearly of interest in these circumstances. Urinary 6-hydroxy melatonin sulphate (aMT6s) is a good index of melatonin secretion in man. In a limited study of seven male volunteers living on an Antarctic base the overall 24-h rhythm of aMT6s excretion was maintained at four different times of year (spring, summer, autumn and winter) and no significant seasonal effects were noted. Cortisol excretion, appeared to be markedly affected by the season although other factors such as social and environmental stress cannot be discounted. These observations suggest that in the absence of a strong light-dark cycle melatonin production may be entrained by other factors.
P A Griffiths; S Folkard; C Bojkowski; J English; J Arendt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experientia     Volume:  42     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  430-2     Citation Subset:  IM    
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MeSH Terms
Antarctic Regions
Circadian Rhythm*
Hydrocortisone / urine*
Melatonin / analogs & derivatives*,  urine
Reg. No./Substance:
2208-41-5/6-hydroxymelatonin; 50-23-7/Hydrocortisone; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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