| Persistence with COX-2 inhibitors in managed care: an analysis of claims data. | |
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MedLine Citation:
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PMID: 14606259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Drug tolerability strongly influences patients' persistence with treatment. In this study, patterns of medication persistence with cyclooxygenase 2 (COX-2)-specific inhibitors and nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs) were compared in a managed care setting. Pharmacy, enrollment, and medical claims data from 19 health plans were used to match subjects newly treated with celecoxib, rofecoxib, ibuprofen, naproxen, or diclofenac between July 1, 1999 and June 30, 2000. By using multiple regression analysis, users of COX-2-specific inhibitors were found to be 56.8% less likely to discontinue medication use and 60.3% less likely to switch treatment than were users of nonspecific NSAIDs (P < .001). Celecoxib users were 4.6% less likely to discontinue treatment than were rofecoxib users (P < .001). The greater persistence observed among users of COX-2 inhibitors might reflect improved treatment efficacy and patient satisfaction. |
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Authors:
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Carolyn Harley; Samuel Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Managed care interface Volume: 16 ISSN: 1096-5645 ISO Abbreviation: Manag Care Interface Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-11-10 Completed Date: 2004-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9715194 Medline TA: Manag Care Interface Country: United States |
Other Details:
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Languages: eng Pagination: 38-45 Citation Subset: H |
Affiliation:
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Research and Data Solutions at Ingenix, Inc., Eden Prairie, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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economics,
therapeutic use* Arthritis / classification, drug therapy*, economics Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors / economics, therapeutic use* Diclofenac / therapeutic use Drug Utilization Review / statistics & numerical data* Female Health Care Costs / classification, statistics & numerical data Humans Ibuprofen / therapeutic use Insurance Claim Review Isoenzymes Lactones / therapeutic use Male Managed Care Programs / economics*, organization & administration Membrane Proteins Middle Aged Naproxen / therapeutic use Patient Compliance / statistics & numerical data* Proportional Hazards Models Prostaglandin-Endoperoxide Synthases Pyrazoles Regression Analysis Sulfonamides / therapeutic use Sulfones United States |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Lactones; 0/Membrane Proteins; 0/Pyrazoles; 0/Sulfonamides; 0/Sulfones; 0/rofecoxib; 15307-86-5/Diclofenac; 15687-27-1/Ibuprofen; 169590-42-5/celecoxib; 22204-53-1/Naproxen; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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