Document Detail


Persistence of polyomavirus in adult SCID C.B-17 mice.
MedLine Citation:
PMID:  7803715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C.B-17 mice with the Severe Combined Immune Deficiency (SCID) mutation were infected with the naturally occurring murine polyomavirus. Using the Polymerase Chain Reaction (PCR) technique, persistence of polyomavirus was followed in different tissues of the mice between 24 hours and 2 months post infection (p.i.). Viral DNA appeared by 3-5 days and was detected in all studied organs by 3 weeks p.i. From 4 weeks to 2 months p.i. viral DNA was present at high levels in all studied organs in all of the animals. As controls normal C.B-17 and A/Sn mice were used. Viral DNA appeared by 2-4 days. The infection reached a peak around 1 week p.i. This was followed by a clearing stage and viral DNA was no longer detectable by 4-5 weeks p.i. Most organs studied with PCR were also examined histologically, but no lesions were observed. Consequently persistence and organ distribution of polyomavirus in adult SCID mice differs greatly from that in normal adult mice.
Authors:
Z Berke; T Dalianis; R Feinstein; K Sandstedt; B Evengard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  8     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1995-01-27     Completed Date:  1995-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  339-42     Citation Subset:  IM    
Affiliation:
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Immunocompetence / physiology*
Mice
Mice, Nude
Mice, SCID / immunology,  virology*
Molecular Sequence Data
Polyomavirus / isolation & purification*
Species Specificity
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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