Document Detail

Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors.
MedLine Citation:
PMID:  11867729     Owner:  NLM     Status:  MEDLINE    
Thyroid hormone (3,5,3'-triiodo-l-thyronine or T3) exerts a pleiotropic activity during central nervous system development. Hypothyroidism during the fetal and postnatal life results in an irreversible mental retardation syndrome. At the cellular level, T3 is known to act on neuronal and glial lineages and to control cell proliferation, apoptosis, migration, and differentiation. Oligodendrocyte precursor cells (OPC) found at birth in the optic nerves are self-renewing cells that normally differentiate during the first 3 weeks of rodent postnatal life into postmitotic myelinating oligodendrocytes. In vitro, the addition of T3 to OPC is sufficient to trigger their terminal differentiation. The present analysis of T3 receptor knockout mice reveals that the absence of all T3 receptor results in the persistence of OPC proliferation in adult optic nerves, in a default in myelination, and sometimes in the degeneration of the retinal ganglion neurons. Thus, T3 signaling is necessary in vivo to promote the complete differentiation of OPC.
Dominique Baas; Claude Legrand; Jacques Samarut; Frédéric Flamant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-02-26
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  99     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2907-11     Citation Subset:  IM    
Centre National de la Recherche Scientifique/Unité Mixte de Recherche, 5665, Institut National de la Recherche Agronomique LA913, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
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MeSH Terms
Animals, Newborn
Cell Differentiation
DNA-Binding Proteins / genetics,  physiology*
Mice, Inbred C57BL
Mice, Knockout
Myelin Sheath / metabolism*
Oligodendroglia / cytology*
Optic Nerve / growth & development,  metabolism*
Receptors, Cytoplasmic and Nuclear / genetics,  physiology*
Receptors, Thyroid Hormone / genetics,  physiology*
Retinal Degeneration / metabolism*
Retinal Ganglion Cells / pathology
Signal Transduction
Stem Cells / cytology*
Triiodothyronine / physiology*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Thyroid Hormone; 6893-02-3/Triiodothyronine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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