| Persistence of memory type lymphocytes in an experimental model of chronic pancreatitis in rats. | |
| | |
MedLine Citation:
|
PMID: 12030436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is growing evidence that immunocompetent cells are involved in the pathogenesis of chronic pancreatitis. Using a model of chronic pancreatitis induced by dibutyltin dichloride (DBTC) in rats, we have immunohistochemically phenotyped the infiltrating T lymphocytes, CD45RC+ cells, macrophages, as well as the IL-2 receptor as an activation marker during a time course of two months. In addition, the expression of CD44, of the integrin component CD18, and of MHC class II was determined. Furthermore, the isoforms of CD45 which are generated by alternative mRNA splicing were analysed using reverse transcription followed by the polymerase chain reaction-technique (RT-PCR). The pattern of the local leukocytes in the DBTC pancreatitis suggests that the acute unspecific inflammation is followed by an activation of T lymphocytes resulting in the chronic course of the disease. |
| | |
Authors:
|
Gisela Sparmann; Sabine Sass; Hans-Joachim Böhme; Stefan Liebe; Jörg Emmrich |
Related Documents
:
|
16920846 - Vanadate but not tungstate prevents the fructose-induced increase in glut5 expression a... 23034716 - Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible fact... 17479246 - Human krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic... 16982746 - Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alp... 18329046 - Dopaminergic receptor d5 mrna expression is increased in circulating lymphocytes of tou... 23104536 - Neuropilin-1 down-regulation impairs cell migration and induces the differentiation of ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cellular and molecular biology (Noisy-le-Grand, France) Volume: 48 ISSN: 0145-5680 ISO Abbreviation: Cell. Mol. Biol. (Noisy-le-grand) Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-05-27 Completed Date: 2003-08-05 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9216789 Medline TA: Cell Mol Biol (Noisy-le-grand) Country: France |
Other Details:
|
Languages: eng Pagination: 309-15 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University Rostock, Germany. gisela.sparmann@med.uni-rostock.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alternative Splicing Animals Antigens, CD18 / metabolism Antigens, CD45 Chronic Disease Disease Models, Animal Ethidium Genes, MHC Class II Immunohistochemistry Immunologic Memory* Macrophages / metabolism Male Organotin Compounds Pancreatitis / immunology* Protein Isoforms Rats Rats, Inbred Lew Receptors, Interleukin-2 / metabolism T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD18; 0/Organotin Compounds; 0/Protein Isoforms; 0/Receptors, Interleukin-2; 3546-21-2/Ethidium; 683-18-1/dibutyldichlorotin; EC 3.1.3.48/Antigens, CD45 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-SLA seropositive autoimmune hepatitis sera recognize distinct subunits of glutathione S-transfe...
Next Document: Differentiation of RNP- and SM-antibody subsets in SLE and MCTD patients by a new ELISA using recomb...