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Persistence of low platelet adhesiveness in von Willebrand disease during pregnancy.
MedLine Citation:
PMID:  20297937     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Platelet adhesiveness (PA) is a valuable measure of ex vivo platelet function. A low PA is a usual feature of von Willebrand disease (vWd). However, PA has rarely been measured during vWd pregnancies. The aim of this work was to observe the behaviour of PA in vWd pregnancies. PA was measured during pregnancy in 33 vWd patients. Intrapregnancy PA remained low without any significant variation compared with non-pregnancy values. Advanced gestation was not accompanied by any increase in PA in spite of the concomitant normalization showed by the other markers of vWd. A low intrapregnancy value was not predictive of an increased risk of bleeding at labour. A low PA could be the only clue for vWd during gestation warranting both a vigilant postpartum attitude and a thorough haemostatic evaluation after pregnancy.
Authors:
C G Fondevila; S Meschengieser; E Bermejo; M A Lazzari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Platelets     Volume:  8     ISSN:  0953-7104     ISO Abbreviation:  Platelets     Publication Date:  1997  
Date Detail:
Created Date:  2010-03-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208117     Medline TA:  Platelets     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  -    
Affiliation:
Department of Thrombosis and Haemostasis, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, de Buenos Aires, Argentina.
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