| Persistence of human papillomavirus infection: keys to malignant progression. | |
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MedLine Citation:
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PMID: 21050765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy. |
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Authors:
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Jason Bodily; Laimonis A Laimins |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-11-01 |
Journal Detail:
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Title: Trends in microbiology Volume: 19 ISSN: 1878-4380 ISO Abbreviation: Trends Microbiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-07 Completed Date: 2011-01-26 Revised Date: 2012-12-04 |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 33-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, 303 E. Chicago Ave, Morton 6-693, Chicago, IL 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alphapapillomavirus
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growth & development,
physiology Animals Cell Transformation, Viral Disease Progression Female Humans Oncogene Proteins, Viral / metabolism Papillomaviridae / growth & development, physiology* Papillomavirus Infections / epidemiology, immunology, pathology* Uterine Cervical Neoplasms / epidemiology, pathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA059655/CA/NCI NIH HHS; R01 CA059655-18/CA/NCI NIH HHS; R01 CA142861-01A1/CA/NCI NIH HHS; R37 CA074202-15/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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