Document Detail


Persistence of effects of nitric oxide synthase inhibitors: comparisons on blood flow and plasma exudation in guinea pig skin.
MedLine Citation:
PMID:  9253959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma protein extravasation has been measured in guinea pig skin using 125I-albumin and blood flow using 133Xenon (133Xe) clearance. The nitric oxide (NO) synthase inhibitors N(G)-nitro-L-arginine methyl ester (L-NAME), N(G)-monomethyl-L-arginine (l-NMMA) and N(G)-nitro-L-arginine (L-NOArg) and the alpha-adrenoceptor agonist, phenylephrine, inhibited bradykinin induced plasma protein extravasation when co-injected with the peptide. The inhibitory effects of L-NAME and L-NOArg lasted for up to 8 and 4 h, respectively, whereas phenylephrine and L-NMMA had no persistent inhibitory effects. When co-injected with 133Xe, L-NAME, L-NMMA, L-NOArg and phenylephrine, but not D-NAME, produced significant reductions in skin blood flow. When injected prior to 133Xe, L-NAME and L-NOArg, but not phenylephrine or L-NMMA, significantly reduced flow. The effect of L-NAME on flow was not significant at 8 h. Thus, although the inhibitory effects of the NO synthase inhibitors on mediator induced plasma protein extravasation show correlations with their effects on blood flow, the persistent effect of L-NAME on exudation appears to extend beyond its effect on flow.
Authors:
A C Perez; A M Khawaja; C P Page; W Paul
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  330     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-22     Completed Date:  1997-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  241-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, King's College London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / pharmacology
Enzyme Inhibitors / pharmacokinetics,  pharmacology*
Exudates and Transudates / drug effects*,  metabolism
Guinea Pigs
Iodine Radioisotopes / diagnostic use
Male
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide Synthase / antagonists & inhibitors*
Nitroarginine / pharmacology
Phenylephrine / pharmacology
Regional Blood Flow / drug effects
Serum Albumin / pharmacokinetics
Skin / blood supply*,  drug effects*
Stereoisomerism
Vasoconstrictor Agents / pharmacology
omega-N-Methylarginine / pharmacology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Iodine Radioisotopes; 0/Serum Albumin; 0/Vasoconstrictor Agents; 17035-90-4/omega-N-Methylarginine; 2149-70-4/Nitroarginine; 50903-99-6/NG-Nitroarginine Methyl Ester; 59-42-7/Phenylephrine; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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