Document Detail

Persistence of crystallin messenger RNA's with reduced translation in hereditary cataracts in mice.
MedLine Citation:
PMID:  7434006     Owner:  NLM     Status:  MEDLINE    
In vitro translation experiments showed that the lens fiber cells of two hereditary cataracts in mice (Nakano and Philly) possessed a full complement of crystallin messenger RNA's, despite severely reduced synthesis of crystallin in these cells. The reduction in synthesis in the lens fiber cells correlated with the increase in Na+ and the decrease in K+, which occurs during cataractogenesis. In contrast to the fiber cells, the epithelial cells continued to synthesize crystallins in the cataractous lenses. Crystallin synthesis was stimulated in the fiber cells by raising the K+ concentration and lowering the Na+ concentration in the cultured lenses. The reduction in crystallin synthesis in the initial stages of cataractogenesis in the Nakano and Philly lenses thus appears to be due to poor utilization of crystallin messenger RNA's in the fiber cells.
T Shinohara; J Piatigorsky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  210     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  914-6     Citation Subset:  IM    
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MeSH Terms
Cataract / genetics,  metabolism*
Crystallins / biosynthesis,  genetics*
Disease Models, Animal
Mice, Mutant Strains / metabolism
Potassium / metabolism
Protein Biosynthesis
RNA, Messenger / metabolism*
Sodium / metabolism
Reg. No./Substance:
0/Crystallins; 0/RNA, Messenger; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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