Document Detail

Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis.
MedLine Citation:
PMID:  15033227     Owner:  NLM     Status:  MEDLINE    
Despite the widespread prescribing of benzodiazepines, uncertainty still surrounds the potential for cognitive impairment following their long-term use. Furthermore, the degree of recovery that may take place after withdrawal or the level of residual impairment, if any, that is maintained in long-term benzodiazepine users is also unclear. The current paper employed meta-analytic techniques to address two questions: (1) Does the cognitive function of long-term benzodiazepine users improve following withdrawal? (2) Are previous long-term benzodiazepine users still impaired at follow-up compared to controls or normative data? Results of the meta-analyses indicated that long-term benzodiazepine users do show recovery of function in many areas after withdrawal. However, there remains a significant impairment in most areas of cognition in comparison to controls or normative data. The findings of this study highlight the problems associated with long-term benzodiazepine therapy and suggest that previous benzodiazepine users would be likely to experience the benefit of improved cognitive functioning after withdrawal. However, the reviewed data did not support full restitution of function, at least in the first 6 months following cessation and suggest that there may be some permanent deficits or deficits that take longer than 6 months to completely recover.
Melinda J Barker; Kenneth M Greenwood; Martin Jackson; Simon F Crowe
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists     Volume:  19     ISSN:  0887-6177     ISO Abbreviation:  Arch Clin Neuropsychol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-22     Completed Date:  2004-05-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9004255     Medline TA:  Arch Clin Neuropsychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-54     Citation Subset:  IM    
School of Psychological Science, La Trobe University, Victoria 3086, Australia.
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MeSH Terms
Benzodiazepines / adverse effects*
Clinical Trials as Topic
Cognition Disorders / chemically induced*,  diagnosis,  psychology
Long-Term Care
Neuropsychological Tests / statistics & numerical data*
Substance Withdrawal Syndrome / diagnosis*,  psychology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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