Document Detail

Persistence of cells capable of T-cell growth factor production in long-term human t-lymphoblast cultures.
MedLine Citation:
PMID:  6977477     Owner:  NLM     Status:  MEDLINE    
Human T-lymphoblasts maintained in culture for 1-2 months in T-cell growth factor conditioned medium continue growth when placed in fresh culture medium in the presence of phytohemagglutinin and irradiated adherent cells. In the absence of lectin, no growth occurs. Neither long-term cells nor irradiated adherent cells plus lectin produce soluble factors that stimulate long-term cell growth, but small amounts of this biologic activity can be detected in the culture medium when the two cell sets are mixed together. The data indicate that human long-term cell populations retain the ability to make enough TCGF to stimulate proliferation, but require physical contact with monocytes in the presence of phytohemagglutinin for this response to occur.
R S Kawahara; J C Rogers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunological communications     Volume:  10     ISSN:  0090-0877     ISO Abbreviation:  Immunol. Commun.     Publication Date:  1981  
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0353016     Medline TA:  Immunol Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-93     Citation Subset:  IM    
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MeSH Terms
Antigen-Antibody Reactions
Cells, Cultured
Culture Media
Growth Substances / metabolism*
Monocytes / immunology,  metabolism
Phytohemagglutinins / immunology
T-Lymphocytes / metabolism*,  physiology
Grant Support
Reg. No./Substance:
0/Culture Media; 0/Growth Substances; 0/Phytohemagglutinins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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