| Persistence of Yersinia enterocolitica in man. | |
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MedLine Citation:
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PMID: 3286508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten patients with chronic Yersinia enterocolitica infections are described. The initial diagnosis was made by culture, significant agglutinin titres and indirect immunofluorescence (IF) on biopsies. During the chronic phase, culture and agglutinin titres were negative, but specific serum IgA and IgG antibodies reactive with at least two, i.e. the 36 kDa and the 46 kDa, virulence-associated released proteins were demonstrated in nine patients by immunoblot techniques. One patient had only IgG antibodies. The chronically elevated IgA production was the result of chronic stimulation of the gut-associated lymphoid tissue by virulent persistent Yersinia antigen, which was identified by IF with O-specific antiserum and monospecific antiserum to the 46 kDa released protein in biopsies. Virulent Yersinia bacilli were demonstrated in the intestinal mucosa and in the lymphoid tissue of the submucosa associated with macrophages in patients with chronic ileitis and arthritis, in granulomatous centres of lymph nodes in patients with chronic lymphadenopathy and in portal infiltrates in a patient with chronic hepatitis. Recognition of persistent Yersinia infections may have therapeutic implications. |
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Authors:
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J A Hoogkamp-Korstanje; J de Koning; J Heesemann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection Volume: 16 ISSN: 0300-8126 ISO Abbreviation: Infection Publication Date: 1988 Mar-Apr |
Date Detail:
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Created Date: 1988-07-08 Completed Date: 1988-07-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0365307 Medline TA: Infection Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 81-5 Citation Subset: IM |
Affiliation:
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Laboratory for Public Health, Leeuwarden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agglutination Tests Antibodies, Bacterial / analysis Arthritis, Infectious / etiology* Chronic Disease Female Fluorescent Antibody Technique Humans Ileitis / etiology* Male Proctitis / etiology* Time Factors Yersinia Infections / diagnosis* Yersinia enterocolitica / immunology, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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