Document Detail


Perp is required for tissue-specific cell survival during zebrafish development.
MedLine Citation:
PMID:  15529176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tumor suppressor p53 has two alternative effects, causing either cell cycle arrest or apoptosis. These different effects are supposed to be mediated by the transcriptional activation of different target genes. perp, encoding a transmembrane protein of the Pmp22 family, is a transcriptional p53 target exclusively upregulated in apoptotic cells. However, its role during normal development had remained largely unclear. Here, we report the isolation and characterization of a zebrafish perp homolog. Upon overexpression in early zebrafish embryos, perp induces apoptosis. In addition, it contributes to p53-dependent and UV-induced cell death. However, during normal zebrafish development, perp displays a p53-independent and spatially restricted expression in specific cell types and tissues. Antisense-mediated loss of Perp function leads to increased apoptosis in perp-expressing cells of the developing skin and notochord. We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival.
Authors:
M Nowak; C Köster; M Hammerschmidt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell death and differentiation     Volume:  12     ISSN:  1350-9047     ISO Abbreviation:  Cell Death Differ.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-09-22     Revised Date:  2013-04-08    
Medline Journal Info:
Nlm Unique ID:  9437445     Medline TA:  Cell Death Differ     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-64     Citation Subset:  IM    
Affiliation:
Max-Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology,  radiation effects
Caspase Inhibitors
Caspases / metabolism
Cell Survival / radiation effects
Cloning, Molecular
Embryo, Nonmammalian / metabolism,  radiation effects
Gene Expression Regulation, Developmental / radiation effects
Membrane Proteins / genetics*,  physiology
Notochord / embryology,  metabolism
Phosphoproteins / genetics
RNA, Messenger / administration & dosage
Skin / embryology,  metabolism
Trans-Activators / genetics
Transcription Factors / genetics
Tumor Suppressor Protein p53 / genetics
Ultraviolet Rays
Zebrafish / embryology*,  genetics
Zebrafish Proteins / genetics*,  physiology
Grant Support
ID/Acronym/Agency:
1R01-GM63904/GM/NIGMS NIH HHS; R01 GM063904/GM/NIGMS NIH HHS; R01 GM063904-01/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Caspase Inhibitors; 0/Membrane Proteins; 0/Perp protein, zebrafish; 0/Phosphoproteins; 0/RNA, Messenger; 0/Trans-Activators; 0/Transcription Factors; 0/Tumor Suppressor Protein p53; 0/Zebrafish Proteins; 0/p73 protein, zebrafish; 0/tp73l protein, zebrafish; EC 3.4.22.-/Caspases

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