| Perp is required for tissue-specific cell survival during zebrafish development. | |
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MedLine Citation:
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PMID: 15529176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tumor suppressor p53 has two alternative effects, causing either cell cycle arrest or apoptosis. These different effects are supposed to be mediated by the transcriptional activation of different target genes. perp, encoding a transmembrane protein of the Pmp22 family, is a transcriptional p53 target exclusively upregulated in apoptotic cells. However, its role during normal development had remained largely unclear. Here, we report the isolation and characterization of a zebrafish perp homolog. Upon overexpression in early zebrafish embryos, perp induces apoptosis. In addition, it contributes to p53-dependent and UV-induced cell death. However, during normal zebrafish development, perp displays a p53-independent and spatially restricted expression in specific cell types and tissues. Antisense-mediated loss of Perp function leads to increased apoptosis in perp-expressing cells of the developing skin and notochord. We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival. |
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Authors:
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M Nowak; C Köster; M Hammerschmidt |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell death and differentiation Volume: 12 ISSN: 1350-9047 ISO Abbreviation: Cell Death Differ. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-09-22 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 9437445 Medline TA: Cell Death Differ Country: England |
Other Details:
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Languages: eng Pagination: 52-64 Citation Subset: IM |
Affiliation:
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Max-Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology, radiation effects Caspase Inhibitors Caspases / metabolism Cell Survival / radiation effects Cloning, Molecular Embryo, Nonmammalian / metabolism, radiation effects Gene Expression Regulation, Developmental / radiation effects Membrane Proteins / genetics*, physiology Notochord / embryology, metabolism Phosphoproteins / genetics RNA, Messenger / administration & dosage Skin / embryology, metabolism Trans-Activators / genetics Transcription Factors / genetics Tumor Suppressor Protein p53 / genetics Ultraviolet Rays Zebrafish / embryology*, genetics Zebrafish Proteins / genetics*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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1R01-GM63904/GM/NIGMS NIH HHS; R01 GM063904/GM/NIGMS NIH HHS; R01 GM063904-01/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caspase Inhibitors; 0/Membrane Proteins; 0/Perp protein, zebrafish; 0/Phosphoproteins; 0/RNA, Messenger; 0/Trans-Activators; 0/Transcription Factors; 0/Tumor Suppressor Protein p53; 0/Zebrafish Proteins; 0/p73 protein, zebrafish; 0/tp73l protein, zebrafish; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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