Document Detail

Peroxynitrite-generating species: good candidate oxidants in aqueous extracts of cigarette smoke.
MedLine Citation:
PMID:  10874594     Owner:  NLM     Status:  MEDLINE    
Cigarette smoking is a well-known risk factor for atherosclerosis, but the mechanism of the adverse biological effect of smoking remains to be established. Cigarette smoke contains high concentrations of free radicals and oxidants. We show here that cigarette smoke extracts (CSE), prepared by bubbling the gas phase of smoke into phosphate-buffered saline, could convert tyrosine to 3-nitrotyrosine. The tyrosine nitration terminated 6 h after incubating tyrosine with CSE at 37 degrees C. These results indicate that the active oxidants in CSE are peroxynitrite-generating species like 3-morpholinosydnonimine (SIN-1), suggesting that they modify plasma lipoproteins and contribute to the pathogenesis of atherosclerosis.
Y Yamaguchi; S Kagota; J Haginaka; M Kunitomo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  82     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-11-01     Completed Date:  2000-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  78-81     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
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MeSH Terms
Nitrates / metabolism*
Oxidants / metabolism
Plants, Toxic*
Smoking / adverse effects
Tobacco / metabolism*
Tyrosine / metabolism
Reg. No./Substance:
0/Nitrates; 0/Oxidants; 0/Smoke; 26404-66-0/peroxynitric acid; 55520-40-6/Tyrosine

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