Document Detail

Peroxynitrite and arachidonic acid. Identification of arachidonate epoxides.
MedLine Citation:
PMID:  7620519     Owner:  NLM     Status:  MEDLINE    
Peroxynitrite is a novel substance capable of oxidation of arachidonic acid. Treatment of [1-14C]arachidonic acid with peroxynitrite at pH 7.4 resulted in formation of a complex mixture of radioactive products. The isolation of these compounds and structural analysis by liquid chromatography/mass spectrometry revealed formation of three epoxyeicosatrienoic acids: 8,9-EET, 11,12-EET and 14,15-EET. These epoxides can play a role in peroxynitrite induced oxidative modification of arachidonic acid in cells.
M Balazy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Polish journal of pharmacology     Volume:  46     ISSN:  1230-6002     ISO Abbreviation:  Pol J Pharmacol     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313882     Medline TA:  Pol J Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  593-600     Citation Subset:  IM    
Department of Pharmacology, New York Medical College, Valhalla 10595, USA.
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MeSH Terms
8,11,14-Eicosatrienoic Acid / analogs & derivatives*,  chemistry,  isolation & purification
Arachidonic Acid / chemistry,  metabolism*
Chromatography, Liquid
Epoxy Compounds / chemistry,  metabolism
Gas Chromatography-Mass Spectrometry
Hydrogen Peroxide / metabolism
Nitrates / chemistry,  metabolism*
Reference Standards
Reg. No./Substance:
0/Epoxy Compounds; 0/Nitrates; 26404-66-0/peroxynitric acid; 506-32-1/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid; 7722-84-1/Hydrogen Peroxide; 81246-85-7/8,9-epoxyeicosatrienoic acid; 81276-02-0/11,12-epoxy-5,8,14-eicosatrienoic acid; 81276-03-1/14,15-epoxy-5,8,11-eicosatrienoic acid

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