| Peroxynitrite and arachidonic acid. Identification of arachidonate epoxides. | |
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MedLine Citation:
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PMID: 7620519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroxynitrite is a novel substance capable of oxidation of arachidonic acid. Treatment of [1-14C]arachidonic acid with peroxynitrite at pH 7.4 resulted in formation of a complex mixture of radioactive products. The isolation of these compounds and structural analysis by liquid chromatography/mass spectrometry revealed formation of three epoxyeicosatrienoic acids: 8,9-EET, 11,12-EET and 14,15-EET. These epoxides can play a role in peroxynitrite induced oxidative modification of arachidonic acid in cells. |
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Authors:
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M Balazy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Polish journal of pharmacology Volume: 46 ISSN: 1230-6002 ISO Abbreviation: Pol J Pharmacol Publication Date: 1994 Nov-Dec |
Date Detail:
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Created Date: 1995-08-31 Completed Date: 1995-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9313882 Medline TA: Pol J Pharmacol Country: POLAND |
Other Details:
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Languages: eng Pagination: 593-600 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, New York Medical College, Valhalla 10595, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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analogs & derivatives*,
chemistry,
isolation & purification Arachidonic Acid / chemistry, metabolism* Chromatography, Liquid Epoxy Compounds / chemistry, metabolism Gas Chromatography-Mass Spectrometry Hydrogen Peroxide / metabolism Nitrates / chemistry, metabolism* Oxidation-Reduction Reference Standards Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Compounds; 0/Nitrates; 26404-66-0/peroxynitric acid; 506-32-1/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid; 7722-84-1/Hydrogen Peroxide; 81246-85-7/8,9-epoxyeicosatrienoic acid; 81276-02-0/11,12-epoxy-5,8,14-eicosatrienoic acid; 81276-03-1/14,15-epoxy-5,8,11-eicosatrienoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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