| Peroxisomes as dynamic organelles: autophagic degradation. | |
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MedLine Citation:
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PMID: 20629742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eukaryotic cells have to regulate peroxisomal metabolism to meet their environmental or developmental requirements. Therefore, the control of peroxisome number, which is mediated not only by proliferation but also by degradation, is an important cellular event. Here we briefly review studies on the autophagic degradation of peroxisomes, a process now termed pexophagy. Recent advances in molecular analyses of both nonselective and selective autophagic pathways have revealed a category of autophagy-related genes (ATG), many of which are shared in different pathways. In this review we introduce the functions of the shared ATG products, along with their interactions with peroxisomal factors. Physiological functions of this process (especially cellular remodeling) in mammalian cells and in a phytopathogenic fungus are also introduced. |
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Authors:
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Masahide Oku; Yasuyoshi Sakai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-12 |
Journal Detail:
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Title: The FEBS journal Volume: 277 ISSN: 1742-4658 ISO Abbreviation: FEBS J. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101229646 Medline TA: FEBS J Country: England |
Other Details:
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Languages: eng Pagination: 3289-94 Citation Subset: IM |
Affiliation:
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Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy* Fungal Proteins / metabolism Humans Organelles / metabolism Peroxisomes / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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